Differential contributions of synaptic and intrinsic inhibitory currents to speech segmentation via flexible phase-locking in neural oscillators
نویسندگان
چکیده
Current hypotheses suggest that speech segmentation—the initial division and grouping of the stream into candidate phrases, syllables, phonemes for further linguistic processing—is executed by a hierarchy oscillators in auditory cortex. Theta (∼3-12 Hz) rhythms play key role phase-locking to recurring acoustic features marking syllable boundaries. Reliable synchronization quasi-rhythmic inputs, whose variable frequency can dip below cortical theta frequencies (down ∼1 Hz), requires “flexible” underlying neuronal mechanisms remain unknown. Using biophysical computational models, we found flexibility neural depended on types hyperpolarizing currents paced them. Simulated flexibly phase-locked slow inputs when these caused both (i) spiking (ii) subsequent buildup outward current sufficient delay until next input. The greatest arose from synergistic interaction between intrinsic was not replicated synaptic at similar timescales. Flexibility enabled improved entrainment input, optimal mid-vocalic channels, which turn supported syllabic-timescale segmentation through identification vocalic nuclei. Our results inhibition contribute frequency-restricted -flexible oscillators, respectively. Their differential deployment may enable diverse roles, reliable internal clocking adaptive quasi-regular sensory like speech.
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ژورنال
عنوان ژورنال: PLOS Computational Biology
سال: 2021
ISSN: ['1553-734X', '1553-7358']
DOI: https://doi.org/10.1371/journal.pcbi.1008783